Linked Life Data

3720828

Source:http://linkedlifedata.com/resource/pubmed/id/3720828

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-8-5
pubmed:abstractText
The calcium antagonists verapamil, bepridil, nifedipine and nimodipine inhibited ATP-dependent 45Ca2+ uptake in purified rat ventricular sarcolemma vesicles dose dependently. This inhibition was preceded by a slight stimulation in the case of the two dihydropyridines, but not with bepridil and verapamil. In contrast, Na+/Ca2+ exchange was only inhibited by verapamil and bepridil and not affected by the dihydropyridines. The steepness of the inhibition curves was significantly different for the two processes. No stereoselectivity was found with either process for inhibition by the verapamil enantiomers. Inhibition of the exchange was not due to a decrease of the exchange velocity but to a decrease in exchange capacity. Variation of the antagonist preincubation time did not modify the inhibition of the uptake. The results indicate that two different sites, located at the inner surface of the sarcolemma are involved in the modulation of the ATP-dependent uptake and the Na+/Ca2+ exchange. However, the possibility cannot be ruled out that inhibition of the exchange process is also mediated by an extracellularly located site.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
441-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Modulation of ATP-dependent calcium extrusion and Na+/Ca2+ exchange across rat cardiac sarcolemma by calcium antagonists.
pubmed:publicationType
Journal Article, In Vitro