Linked Life Data

3719517

Source:http://linkedlifedata.com/resource/pubmed/id/3719517

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-8-6
pubmed:abstractText
A 17-month-old infant with clinical and pathologic features of acute megakaryoblastic leukemia and myelofibrosis developed soft tissue metastases. Tissue from an orbital metastasis was biopsied and transplanted into a nude mouse. Histologically the tumor was composed of pleomorphic cells with single convoluted nuclei or multilobed nuclei and prominent granular cytoplasm and had an alveolar histologic pattern in some areas. The ultrastructural features of the tumor cells include multilobed nuclei with prominent nucleoli and cytoplasmic granules with the characteristics of alpha-granules. The tumor has been successfully passaged over a 1-year interval and appears to be a stable megakaryoblastic tumor cell line (CHRF-288). Cells from the tumor line are reactive for factor VIII related antigen and also have GpIIb IIIa complex antigen on the plasma membrane surface. This tumor line may be a useful system for investigation of megakaryocytic functions including the production and regulation of the various factors they produce.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0008-543X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
238-44
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Megakaryoblastic leukemia in an infant. Establishment of a megakaryocytic tumor cell line in athymic nude mice.
pubmed:publicationType
Journal Article, Case Reports