Linked Life Data

3719320

Source:http://linkedlifedata.com/resource/pubmed/id/3719320

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-7-29
pubmed:abstractText
In rats under urethane or pentobarbitone anesthesia, Ca2+ -sensitive microelectrodes were inserted into CA3 and CA1 hippocampal cells. In 23 neurons with a mean resting membrane potential (Vm) of -56.9 mV, the Ca potential (VCa) fell below Vm by an average of -22.1 mV (S.D. +/- 19.1 mV), indicating a mean intracellular free Ca2+ concentration ([Ca]i) of 9.7 microM (S.D. 14.9 microM). In spite of their better and more stable Vm (mean -67.1 mV), unresponsive cells (probably neuroglia) had a higher and more variable [Ca]i (mean 37.0 +/- 51.2 microM). In 21 of the neurons, repetitive stimulation of the fimbria--at 5-20 Hz for 30s, which is sufficient to elicit bursts of population spikes--evoked substantial increases in [Ca]i: the mean increase observed during or just after 29 such tetani was +27.1 +/- 54.5 microM. Typically [Ca]i reached a peak near the end of the tetanus and then decayed with a half-time of 5-10 s, though not necessarily to the initial level. In 7 cells, a large increase in [Ca] (mean +239 +/- 367 microM) appeared as a late event, 20-30 s after the end of the tetanus. In 5 cells, [Ca]i could thus be raised transiently to 10(-4) M or higher. All these increases in [Ca]i are far greater than can be evoked by tetanic activation in spinal motoneurons; their possible significance for long term potentiation or cell necrosis in the hippocampus is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
374
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Changes in free calcium ion concentration recorded inside hippocampal pyramidal cells in situ.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't