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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
5
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pubmed:dateCreated |
1986-7-25
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pubmed:abstractText |
The pharmacokinetics of S-(+)- and R-(-)-mexiletine and of the corresponding conjugates were investigated in six healthy young volunteers after administration of a single 200 mg oral dose of racemic mexiletine hydrochloride. The values for the distribution rate constants as well as for the elimination half-lives of the two enantiomers were similar but the AUC of the S-(+)-enantiomer was always significantly higher (P less than 0.01) than that of the opposite enantiomer. The mean R/S ratios for unchanged mexiletine in serum and in urine were 0.78 +/- 0.12 (s.d.) and 0.80 +/- 0.21, respectively. Urinary excretion of mexiletine conjugates consisted mainly of the R-(-)-enantiomer; the mean R/S enantiomeric ratio over 48 h was 9.65 +/- 3.10. Serum concentrations of the conjugates were measured in three subjects. The mean R/S AUC ratio was 2.94 +/- 0.48 and the renal clearance of the R-(-)-enantiomer was significantly higher (P less than 0.02) than that of the S-(+)-enantiomer.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-17691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-17857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-2862002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-378646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-3980650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-4006363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-4124889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-4124890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-4146584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-4605176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-513064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6092093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6126341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6130908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6144480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6148215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6409913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6437721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6440790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6480762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6490241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6508982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6508983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6641085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6721991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-6734027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-678385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-698033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-7097538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-7354440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718807-876954
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0306-5251
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
481-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
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pubmed:year |
1986
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pubmed:articleTitle |
Stereoselective disposition of mexiletine in man.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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