rdf:type |
|
lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0016030,
umls-concept:C0018670,
umls-concept:C0023823,
umls-concept:C0031676,
umls-concept:C0086418,
umls-concept:C0813983,
umls-concept:C0947647,
umls-concept:C1158917,
umls-concept:C1257890,
umls-concept:C1280500
|
pubmed:issue |
1
|
pubmed:dateCreated |
1986-7-18
|
pubmed:abstractText |
Modification of phospholipid polar head group was achieved by growing human cultured fibroblasts in medium devoid of serum and supplemented with N-methyl ethanolamine or N,N-dimethylethanolamine during 48 h. The corresponding phospholipids accounted for approximately 45% of total phospholipids. Whereas low density lipoprotein (LDL) binding was unaffected, LDL internalization and degradation appeared to be markedly reduced in the presence of N-methylethanolamine. N,N-dimethylethanolamine had no effect on the three studied parameters. These results emphasize the importance of phospholipid polar head group in LDL processing by receptor-mediated endocytosis.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0006-291X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
29
|
pubmed:volume |
137
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
43-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3718513-Cells, Cultured,
pubmed-meshheading:3718513-Choline,
pubmed-meshheading:3718513-Endocytosis,
pubmed-meshheading:3718513-Fibroblasts,
pubmed-meshheading:3718513-Humans,
pubmed-meshheading:3718513-Lipoproteins, LDL,
pubmed-meshheading:3718513-Membrane Lipids,
pubmed-meshheading:3718513-Phospholipids,
pubmed-meshheading:3718513-Receptors, LDL,
pubmed-meshheading:3718513-Structure-Activity Relationship,
pubmed-meshheading:3718513-Temperature
|
pubmed:year |
1986
|
pubmed:articleTitle |
Effect of manipulation of phospholipid polar head group on low density lipoprotein metabolism in human cultured fibroblasts.
|
pubmed:publicationType |
Journal Article,
In Vitro
|