Linked Life Data

3718082

Source:http://linkedlifedata.com/resource/pubmed/id/3718082

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-7-18
pubmed:abstractText
The effect of nifedipine and niludipine on ischemic myocardial pH was studied. To make the myocardium ischemic (60% reduction of coronary flow), the left anterior descending coronary artery (LAD) was partially occluded 30 min before either vehicle (1% ethanol solution) or drugs were injected intravenously. In the non-occlusion group, nifedipine (10 micrograms/kg) and niludipine (10 micrograms/kg) increased coronary flow, decreased blood pressure, and did not change myocardial pH appreciably. In the partial occlusion group, reduction of coronary flow decreased the myocardial pH, increased ST segment, and did not change heart rate and blood pressure. Vehicle was injected 30 min after the occlusion, but did not change any of the parameters. A small dose (1 microgram/kg) and a large dose (10 micrograms/kg) of nifedipine, and niludipine (10 micrograms/kg) did not exert any beneficial effect on the myocardial pH, coronary flow and the ST segment during coronary occlusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0301-4533
pubmed:author
pubmed:issnType
Print
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
58-73
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effect of nifedipine and niludipine on myocardial pH in the ischemic canine heart.
pubmed:publicationType
Journal Article