Linked Life Data

3718076

Source:http://linkedlifedata.com/resource/pubmed/id/3718076

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-7-18
pubmed:abstractText
The effects of verapamil on the dopamine-induced pancreatic exocrine secretion were investigated in the isolated and blood-perfused canine pancreas at a constant flow rate in situ. All drugs were given intra-arterially. Dose-related increases in the volume of pancreatic secretion induced by dopamine (1-10 micrograms) were reduced by infusion of 50 and 100 micrograms/min of verapamil, but were not affected by diltiazem (100 micrograms/min) and dilazep (100 micrograms/min) infusions. Protein concentration in pancreatic juice induced by dopamine was decreased significantly by the infusion of verapamil, diltiazem and dilazep, but bicarbonate concentration was not. These results suggest that verapamil reduced the dopamine-induced pancreatic secretion by virtue of its dopamine antagonist activity and inhibited protein secretion by virtue of its calcium channel blocking action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0301-4533
pubmed:author
pubmed:issnType
Print
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-52
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Blocking effects of verapamil on pancreatic exocrine secretion induced by dopamine in the dog.
pubmed:publicationType
Journal Article