Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-6-27
pubmed:abstractText
A quantitative mouse calvarial bone resorption assay was employed to investigate the effects of the mast cell products, heparin and histamine, and of salmon calcitonin. 'Amorphous' heparin, containing a range of molecular weight fractions, inhibited resorption by 15-20% at concentrations of 0.75-5.0 mg/ml. A 'defined' heparin species of mol.wt 13 500 inhibited resorption by 14-28% at 10(-5)-10(-4) mol/l. Histamine inhibited resorption by 19-55% at 10(-3)-10(-2) mol/l. It is proposed that heparin and histamine depress coupled bone resorption and formation and may lead to net loss of bone. Salmon calcitonin inhibited resorption at concentrations as low as 10 pg/ml. 'Amorphous' (but not 'defined') heparin blunted calcitonin induced inhibition of bone resorption and may derepress osteoclasts.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-1158887, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-123694, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-13319388, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-14221490, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-14304362, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-14304374, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-145375, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-222339, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-439319, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-4718297, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-4891295, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-500822, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-5434445, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-6089675, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-6205434, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-6445388, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-6466393, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-6652051, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-6888159, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-7003392, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-7126643, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-7287812, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-7289874, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-830557, http://linkedlifedata.com/resource/pubmed/commentcorrection/3718018-859561
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0003-4967
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
422-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effects of heparin, histamine, and salmon calcitonin on mouse calvarial bone resorption.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't