Linked Life Data

3717495

Source:http://linkedlifedata.com/resource/pubmed/id/3717495

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-7-9
pubmed:abstractText
Seventy-five premenopausal women autopsied under medical examiner auspices were selected for a correlative study of breast and endometrial morphology proceeding through the menstrual cycle. Criteria for selection included adequate preservation of the endometrial and breast tissue, relatively even distribution of women by age (range 15-56), menstrual cycle date, and parity status. Hormonal therapy and disease states that might influence pituitary-ovarian cycling were reasons for exclusion from the study. Proliferative phase breast was characterized by small lobules with few terminal duct structures. Terminal duct epithelial mitoses were uncommon. Intralobular stroma was condensed and continuous with interlobular stroma. Secretory phase breasts were characterized by increasing size of lobules and number of terminal duct structures and duct epithelial basal vacuolization and mitoses. Intralobular stroma became increasingly loose and edematous. Stromal lymphocytic population increased toward the end of secretory phase. Perimenstrual breasts underwent lobular contraction with necrosis and sloughing of duct epithelium. There was a concomitant marked increase in lobular stromal lymphocytic infiltrate and metachromasia. These features heralded a return to the proliferative phase appearance. These marked cyclical changes have implications for routine pathologic diagnosis as well as for the newer noninvasive diagnostic techniques.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0147-5185
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
382-93
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
A correlative morphologic study of human breast and endometrium in the menstrual cycle.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.