Linked Life Data

3717353

Source:http://linkedlifedata.com/resource/pubmed/id/3717353

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 2
pubmed:dateCreated
1986-7-24
pubmed:abstractText
The possible contribution of circulating dopamine sulfate to urinary free dopamine and the synthesis of norepinephrine by the renal nerves were examined in the isolated perfused rat kidney. Perfusion of the kidney with dopamine sulfate did not yield significant amounts of free dopamine indicating that, unlike L-dopa, dopamine sulfate is not a good source of urinary free dopamine. The excretion of dopamine sulfate was slower than or comparable with that of free dopamine, suggesting that sulfoconjugation is not a mechanism to facilitate the excretion of free dopamine. Unlike free dopamine, dopamine sulfate was not metabolized by renal catechol-O-methyltransferase or monoamine oxidase. Perfusion of L-dopa and free dopamine led to the generation of norepinephrine in the kidney. This synthesis was abolished when the kidney was denervated, suggesting that the renal nerves were the main sites of the norepinephrine synthesis. Both norepinephrine and dopamine were rapidly metabolized by catechol-O-methyltransferase and monoamine oxidase, but renal phenolsulfotransferase appeared to have no action on the catecholamines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
250
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
F975-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Handling of dopamine and dopamine sulfate by isolated perfused rat kidney.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't