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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1986-7-3
|
| pubmed:abstractText |
Twenty-five children with steroid-responsive idiopathic nephrotic syndrome were studied for persistence of antipneumococcal capsular polysaccharide antibody during relapse of their disease and at 1, 6, and 12 months after vaccination with the 14-valent pneumococcal vaccine. Nonrelapsers (group I) were compared to those who had at least one relapse but whose sera were obtained during remission (group II). Group II had a more rapid decline in total anticapsular antibody per month than group I (5.3% v 2.4%). Analysis by individual anticapsular types showed that differences between groups approached significance only for type 4 (P = .07). Rates of decline of antibody against pneumococcal capsular polysaccharide varied among types. One year after vaccination, 50% of patients had less than 300 ngAbN/mL against types 4, 6A, 7F, 8, and 19F. Sera obtained from seven patients during relapse had geometric mean antibody concentrations less than 300 ngAbN/mL against those same types; two of these types have been reported to cause disease in vaccinated patients with nephrosis. Decline of antibody against pneumococcal capsular polysaccharide following vaccination varies by capsular type. Type-specific analysis should be used when monitoring serum antibody levels in these patients after vaccination.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0272-6386
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
466-70
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3717153-Adolescent,
pubmed-meshheading:3717153-Antibodies, Bacterial,
pubmed-meshheading:3717153-Bacterial Vaccines,
pubmed-meshheading:3717153-Child,
pubmed-meshheading:3717153-Child, Preschool,
pubmed-meshheading:3717153-Female,
pubmed-meshheading:3717153-Glomerulonephritis,
pubmed-meshheading:3717153-Humans,
pubmed-meshheading:3717153-Male,
pubmed-meshheading:3717153-Nephrotic Syndrome,
pubmed-meshheading:3717153-Pneumococcal Infections,
pubmed-meshheading:3717153-Proteinuria,
pubmed-meshheading:3717153-Radioimmunoassay,
pubmed-meshheading:3717153-Recurrence,
pubmed-meshheading:3717153-Risk,
pubmed-meshheading:3717153-Streptococcus pneumoniae,
pubmed-meshheading:3717153-Time Factors,
pubmed-meshheading:3717153-Vaccination
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Decline of vaccine-induced antipneumococcal antibody in children with nephrotic syndrome.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|