Linked Life Data

3714863

Source:http://linkedlifedata.com/resource/pubmed/id/3714863

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-7-2
pubmed:abstractText
Among the compromised physiological responses affected by aging is an impaired ability to thermoregulate in a cold environment. Since acute exposure to cold-water swims (CWS) produces both analgesic and hypothermic responses in young adult rats, the present study examined whether systematic variations in these responses occurred as a function of age. Separate cohorts of 4, 9, 14, 19 and 24-month old female rats received a no-swim condition and a 2 degrees C swim for 3.5 min with tail-flick latencies, jump thresholds and core body temperature assessed 30, 60 and 90 min later. The order of conditions was counterbalanced with an interval of four days between conditions. While the four younger cohorts displayed similar CWS analgesia on the tail-flick test, the 24-month cohort failed to display CWS analgesia on this measure. Age-related differences in CWS analgesia on the jump test appeared more gradual with the three older cohorts displaying significant attenuations relative to the 9-month group, and the oldest cohort displaying significant attenuations relative to the 4-month group. In contrast, the hypothermic effect of CWS was significantly potentiated in the three oldest cohorts, with a progressive inability to cope with thermoregulation observed as a function of age. The observed decrements in the analgesic response to CWS as a function of age appear to represent a change in (a) the ability of the animal to perceive the CWS stimulus as stressful (b) an endogenous pain-inhibitory system and/or (c) an endogenous pain transmission system that is independent of thermoregulatory mechanisms.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
875-80
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Age-related decrements in the analgesic response to cold-water swims.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't