Linked Life Data

3714356

Source:http://linkedlifedata.com/resource/pubmed/id/3714356

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-6-27
pubmed:abstractText
Cerebral ischemia and intracranial hemorrhage are the most important causes of perinatal brain damage and their pathogenesis seems to be interrelated. Several components in blood have been shown to cause contraction of cerebral blood vessels. In the present study we examined the changes with time of the concentration of standard electrolytes in a mixture of blood and mock cerebrospinal fluid, whether these changes may affect cerebrovascular tone, and if calcium blockers could influence such an effect. Extracellular K+ increased to about 23 mM 4 days after mixing when half of the mixture consisted of blood, and remained nearly constant for at least 8 days thereafter. Using isometric recording of circular tension in a controlled tissue bath it was found that isolated human pial arterioles, small arteries, and feline middle cerebral arteries contracted markedly when K+ exceeded 10 and 20 mM, respectively. It is concluded that neonatal perihemorrhagic ischemia may be, at least partly, due to leakage of K+ from the erythrocytes. The contractile effect of extracellular K+ is effectively counteracted by Ca++ entry blockers, which therefore may have a role in the prevention of perihemorrhagic ischemia in neonates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
478-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
On the pathogenesis of regional cerebral ischemia in intracranial hemorrhage: a causal influence of potassium?
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't