Linked Life Data

3712214

Source:http://linkedlifedata.com/resource/pubmed/id/3712214

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-7-18
pubmed:abstractText
The absorption and lymphatic delivery of a new immunosuppressive drug, cyclosporin A (CsA), with the aid of lipid surfactant mixed micelles (MM) system using different administration routes were studied in the thoracic duct cannulated rat model at a dose level of 7 mg/kg. The rectal or intraperitoneal (i.p.) administration of CsA indicated a small amount of CsA in the plasma and in the lymph for 6 h. As oral routes, intrastomach (i.s.) and intraduodenal (i.d.) administration of CsA were performed and high lymph CsA levels were obtained. The i.s. administration of CsA resulted in the highest CsA levels in the lymph, 16 micrograms/ml, about twenty times higher than the rectal or i.p. administration. These results strongly support the usefulness of an oral CsA dosage form for the selective lymphatic delivery of CsA in clinical immunosuppressive therapy by means of a new mixed micelles system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0386-846X
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
156-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effect of administration route on the selective lymphatic delivery of cyclosporin A by lipid-surfactant mixed micelles.
pubmed:publicationType
Journal Article