Linked Life Data

3711668

Source:http://linkedlifedata.com/resource/pubmed/id/3711668

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-7-18
pubmed:abstractText
High titers of IgG2a-specific rheumatoid factors (RF) are frequently observed in colonies of 129/Sv mice. The involvement of a transmissible agent in this phenomenon was shown by the following findings: (i) cesarean-derived and isolator-reared offsprings of RF-positive dams were free of RF, ii) a single intragastric inoculation with intestinal fluid from RF-positive donors elicited chronic RF production in RF-negative recipients, and iii) intestinal fluid collected from these primary recipients induced a comparable RF response in a second set of animals. The nature of this RF-inducing agent, however, remained elusive. Although its ability to pass through filters that efficiently retained bacteria could be unequivocally established, systematic serological analysis failed to detect any significant correlation between RF production and antibody responses to common mouse viruses or Mycoplasma. Moreover, all attempts to identify the RF-inducing agent by electron microscopy or to grow it in nude or newborn mice, as well as in cell cultures, remained unsuccessful.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
137
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Rheumatoid factor production in 129/Sv mice: involvement of an intestinal infectious agent.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't