Linked Life Data

3711510

Source:http://linkedlifedata.com/resource/pubmed/id/3711510

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-7-18
pubmed:abstractText
Previous studies have suggested that there exists a functional border zone in myocardium at the lateral margins of an ischemic area. The functional border zone is normally perfused but is characterized by abnormal contractile function. To define the spatial characteristics of this border zone, circumferential maps of left ventricular function by two-dimensional echocardiography and of coronary flow using radioactive microspheres were generated in 18 dogs at baseline and after circumflex coronary occlusion. Circumferential left ventricular wall thickening was measured in all dogs at 22.5 degrees intervals over 360 degrees. In seven dogs, the pathologic slice corresponding to the two-dimensional echocardiographic image was circumferentially dissected into 16 segments corresponding to 22.5 degrees intervals and a subendocardial myocardial blood flow map was derived. In the other 11 dogs, autoradiography was performed of the pathologic slice corresponding to the two-dimensional echocardiographic image, and the hypoperfusion zone was directly measured. There was no difference between the circumferential extent of hypoperfusion zones by either perfusion measurement technique in the five dogs that had both techniques performed (140 +/- 12 versus 124 +/- 7 degrees, p = NS). The hypofunctional zone by two-dimensional echocardiography was significantly larger than the hypoperfusion zone (174 +/- 4 versus 125 +/- 26 degrees, p less than 0.0005), indicating that a zone of normally perfused but abnormally contracting muscle surrounds the ischemic area. However, this border zone in our model was small, measuring 49 +/- 34 degrees (approximately 8 to 9 mm on either lateral border). This suggests that the functional border zone lateral to ischemic myocardium exists, but is relatively discrete.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0735-1097
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
150-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Characterization of the functional border zone around regionally ischemic myocardium using circumferential flow-function maps.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't