| pubmed-article:3710558 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3710558 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:3710558 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3710558 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3710558 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:3710558 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:3710558 | lifeskim:mentions | umls-concept:C0011710 | lld:lifeskim |
| pubmed-article:3710558 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:3710558 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3710558 | pubmed:dateCreated | 1986-7-16 | lld:pubmed |
| pubmed-article:3710558 | pubmed:abstractText | This study investigated the effects of altered extracellular Ca2+ on in vitro femoral arterial smooth muscle responsiveness in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Compared with controls, femoral arteries from DOCA-salt rats showed a significant increase in sensitivity to KCl and norepinephrine in normal Ca2+ (2.5 mM). Although no difference in maximal contractile response to KCl was observed between groups, there was a significant difference in maximal response to norepinephrine. Dose-response curves in low Ca2+ (0.25 mM) resulted in a significant decrease in the sensitivity of femoral arteries from DOCA-salt rats to KCl and NE so that the responses were similar to those of controls. Relaxation of femoral arteries from DOCA-salt rats after washout of the KCl contraction was significantly slower than that of controls in both low and normal Ca2+. Isoproterenol-induced relaxation of femoral arteries from DOCA-salt rats was significantly attenuated in normal Ca2+. Sensitivity of femoral arteries from DOCA-salt rats to isoproterenol increased in low Ca2+, but maximal relaxation was unaltered. Whereas no difference in maximal relaxation to NaNO2 was seen in femoral arteries from either group in normal Ca2+, a significant decrease in sensitivity to NaNO2 was observed in femoral arteries from DOCA-salt rats. In low Ca2+ the response of femoral arteries from DOCA-salt rats to NaNO2 was similar to that of controls. These results suggest that the increased vascular smooth muscle responsiveness to KCl and norepinephrine seen in DOCA-salt hypertension is due to increased sensitivity of the vascular smooth muscle to Ca2+. Extracellular Ca2+, however, plays only a minor role in the decreased vasodilator responsiveness seen in this form of hypertension. | lld:pubmed |
| pubmed-article:3710558 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3710558 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3710558 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3710558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3710558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3710558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3710558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3710558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3710558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3710558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3710558 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3710558 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3710558 | pubmed:issn | 0194-911X | lld:pubmed |
| pubmed-article:3710558 | pubmed:author | pubmed-author:FieldF PFP | lld:pubmed |
| pubmed-article:3710558 | pubmed:author | pubmed-author:SoltisE EEE | lld:pubmed |
| pubmed-article:3710558 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3710558 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:3710558 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3710558 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3710558 | pubmed:pagination | 526-32 | lld:pubmed |
| pubmed-article:3710558 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3710558 | pubmed:meshHeading | pubmed-meshheading:3710558-... | lld:pubmed |
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| pubmed-article:3710558 | pubmed:meshHeading | pubmed-meshheading:3710558-... | lld:pubmed |
| pubmed-article:3710558 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3710558 | pubmed:articleTitle | Extracellular calcium and altered vascular responsiveness in the deoxycorticosterone acetate-salt rat. | lld:pubmed |
| pubmed-article:3710558 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3710558 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
