Linked Life Data

3709809

Source:http://linkedlifedata.com/resource/pubmed/id/3709809

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-7-14
pubmed:abstractText
The effect of 12-O-tetradecanoylphorbol 13-acetate (TPA) on acid secretion by rat stomach in vivo has been investigated to establish whether a previously determined inhibitory effect of TPA on aminopyrine accumulation by isolated parietal cells genuinely reflected a reduced acid secretion. Perfusion of 1 microM TPA through the lumen of the stomach had little effect on basal or carbachol-stimulated secretion, but inhibited secretion induced by histamine or pentagastrin. 4 alpha-Phorbol 12,13-didecanoate did not affect pentagastrin-stimulated secretion. It is concluded that TPA exerts a specific inhibitory effect on acid secretion in vivo, which parallels that found on aminopyrine accumulation in isolated parietal cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
201
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Inhibitory effect of 12-O-tetradecanoylphorbol 13-acetate on acid secretion by rat stomach in vivo.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't