Linked Life Data

3709704

Source:http://linkedlifedata.com/resource/pubmed/id/3709704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-7-1
pubmed:abstractText
The erythropoietic response, measured as 59Fe uptake by RBC, and the erythropoietin content of kidney tissue after exposure to hypobaric hypoxia were determined in both posthypoxic (PH) and hypertransfused (HT) rats. Plasma Ep titers were also measured in both PH and HT nephrectomized rats treated similarly. PH and HT rats with similar degrees of polycythemia greatly differed in their responses to hypoxia, with radioiron uptake by RBC about six times higher in the former than in the latter. Kidney Ep titers were significantly enhanced after exposure to hypoxia in either normal or polycythemic rats. However, kidney Ep titers in PH rats were significantly higher than the values found in normal or HT rats. Plasma Ep titers in both PH and HT nephrectomized rats exposed to hypoxia were similar and significantly lower than the plasma values of normal or nephrectomized, nonpolycythemic rats treated similarly. These results suggest that exposure to hypoxia induces sensitization of the renal, but not extrarenal, mechanism involved in Ep production.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Hypoxia-induced renal and extrarenal erythropoietin production in posthypoxic or hypertransfused polycythemic rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't