Linked Life Data

3708938

Source:http://linkedlifedata.com/resource/pubmed/id/3708938

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-7-7
pubmed:abstractText
We investigated whole kidney function and electrolyte transport in the loop of Henle of surface nephrons using micropuncture in rats pretreated for 5-7 days with cyclosporine A (CSA, 15 mg/kg). We also studied whether the kidney was able to increase K+ excretion acutely after a period of acute i.v. KCl loading (37 mumol/min.kg body weight). For Henle loop studies we microperfused the late proximal tubule downstream from an immobile wax block at two perfusion rates (15 and 40 nl/min). The fluid at the beginning distal tubule was collected and analyzed for inulin, Na+, K+, Cl-, Ca++, and Mg++. Plasma levels of CSA in our model ranged from 254 and 971 ng/ml and showed no relation to the obtained measurements. The pretreatment with CSA did not significantly change whole kidney or Henle loop electrolyte transport compared to drug free controls. Also, the CSA-pretreated rats were able to excrete an acute KCl load although this was at the expense of a marginally higher plasma K+ concentration and also a smaller urine flow increase during KCl loading. Thus CSA-pretreated rats showed only a mildly impaired response to KCl challenge in the absence of GFR impairment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0430
pubmed:author
pubmed:issnType
Print
pubmed:volume
25 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S57-61
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effect of cyclosporine A on renal electrolyte transport: whole kidney and Henle loop study.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't