Linked Life Data

3708932

Source:http://linkedlifedata.com/resource/pubmed/id/3708932

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-7-7
pubmed:abstractText
Cyclosporine (CSA) nephrotoxicity was investigated in the rat. Morphologically, CSA nephrotoxicity is characterized by the following features: (a) Tubular inclusion bodies (TIB) corresponding to autolysosomes and giant mitochondria; (b) tubular vacuolization (TV) due to dilatation of the endoplasmatic reticulum; (c) tubular microcalcification (TM); and (d) tubular regeneration (TR). The morphologic features are limited to (a and b) or predominate (c and d) in the proximal tubule. CSA tubulopathy as defined above is dose dependent, independent of the route of a drug administration, develops quickly (within a week), is reversible after CSA withdrawal, is more pronounced in male than in female rats and shows no clear cut differences in various rat strains. Body weight shows a dose dependent reduction. The functional changes are usually slight. No significant correlation exists between functional changes and morphologic lesions. The type of CSA nephrotoxicity in the rat is very similar to CSA-tubulopathy in man but associated with less severe functional changes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0430
pubmed:author
pubmed:issnType
Print
pubmed:volume
25 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S2-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Morphology of cyclosporine nephrotoxicity in the rat.
pubmed:publicationType
Journal Article