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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1986-6-30
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pubmed:abstractText |
In spontaneously beating atria from reserpine-treated guinea-pigs, amrinone (10 microM to 2 mM) induced a positive inotropic and chronotropic effect that was preceded by a transient reduction in contractile force and in frequency. Both the positive and negative effects were concentration-dependent. The inotropic action of amrinone was antagonized by low concentrations of 8-phenyltheophylline that compete with adenosine at R-receptors on plasma membrane without significantly influencing phosphodiesterase activity. Cumulative concentrations of amrinone (1 mM) antagonized the reduction of rate of contraction and amplitude induced by dipyridamole 1 microM in spontaneously beating atria and restored the maximum contractile effect reached in the absence of dipyridamole. In spontaneously beating preparations incubated in the presence of adenosine deaminase (1 u ml-1), amrinone lost its positive effects on the atria and only reduction of rate and contractile force was evident. Both effects were antagonized by scopolamine 1 mM thus indicating their cholinergic nature. Adenosine at 0.1 microM and 0.5 microM significantly inhibited the inotropic effect induced by amrinone (0.03 to 3 mM) and the concentration-effect curves of amrinone obtained in the absence and presence of adenosine clearly indicate a competitive antagonism between the two drugs. Thus the contractile activity of amrinone in spontaneously beating atria from reserpine-treated guinea-pigs originates from a displacement of adenosine from its R-receptor sites in the cardiac cell.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-201831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-225626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-39684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-436202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-509428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6177950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6188912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6200717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6200719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6243565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6256173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6260118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6267486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6276787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6283063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6360634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6584209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6728037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6844374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-6861291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-714115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3708202-7246440
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
623-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3708202-Adenosine,
pubmed-meshheading:3708202-Adenosine Deaminase,
pubmed-meshheading:3708202-Aminopyridines,
pubmed-meshheading:3708202-Amrinone,
pubmed-meshheading:3708202-Animals,
pubmed-meshheading:3708202-Cardiac Glycosides,
pubmed-meshheading:3708202-Cardiotonic Agents,
pubmed-meshheading:3708202-Dipyridamole,
pubmed-meshheading:3708202-Guinea Pigs,
pubmed-meshheading:3708202-Heart,
pubmed-meshheading:3708202-Heart Atria,
pubmed-meshheading:3708202-Male,
pubmed-meshheading:3708202-Myocardial Contraction,
pubmed-meshheading:3708202-Reserpine,
pubmed-meshheading:3708202-Theophylline
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pubmed:year |
1986
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pubmed:articleTitle |
Interaction of amrinone with endogenous adenosine in guinea-pig atria.
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pubmed:publicationType |
Journal Article,
In Vitro
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