Linked Life Data

3707800

Source:http://linkedlifedata.com/resource/pubmed/id/3707800

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-7-18
pubmed:abstractText
In 40 patients anaesthetized with thiopentone, 66% nitrous oxide and 1% halothane, the effects of a single i.v. dose of nalbuphine 4.5, 8, 15, 25 or 50 mg/70 kg or morphine 3, 5, 10 or 17.5 mg/70 kg on total ventilation and end-tidal carbon dioxide concentration have been measured. Depression of respiration occurred with both drugs and with all doses. The lower doses of nalbuphine produced more depression than equianalgesic doses of morphine. Conventional equianalgesic doses produced similar degrees of depression. With the highest dose of morphine, respiratory impairment progressed to apnoea whereas, with nalbuphine, apnoea did not occur in any patient. With increasing dosage of nalbuphine there appeared to be a limit to the extent of respiratory depression. The highest dose of nalbuphine produced less depression than some lower doses, suggesting a reversal effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-0912
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
625-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Respiratory function following nalbuphine and morphine in anaesthetized man.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial