Linked Life Data

3707651

Source:http://linkedlifedata.com/resource/pubmed/id/3707651

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2A
pubmed:dateCreated
1986-5-28
pubmed:abstractText
The electrophysiological properties of ibopamine (SB-7505), the 3,4-diisobutyryl ester N-methyldopamine, was evaluated in 8 patients with syncopes of unknown etiology or with suspected disease of the sinus node or due to I-II degree AV block. A complete electrophysiological examination, including atrial and ventricular stimulation, was performed both in baseline conditions and within 1 h after oral administration of ibopamine 200 mg in a single dose. The study showed a slight reduction in effective refractory periods in the right atrium (-4.26%), the atrio-ventricular node (-6.45%) and the right ventricle (-6.79%) after ibopamine. Ibopamine was not found to facilitate the occurrence of atrial and/or ventricular arrhythmias. A 24-h dynamic Holter ECG performed in baseline conditions and during administration of ibopamine 200 mg t.i.d. showed no changes in baseline heart rate, nor was any increase in the number of atrial or ventricular extrasystoles detectable. It may therefore be concluded that ibopamine, when administered at the above dosages to the patients studied, does not modify heart rate or sinus function parameters to a statistically significant extent. It also reduces effective refractory periods in the right atrium, in the atrioventricular node and in the right ventricle without inducing or facilitating the occurrence of atrial or ventricular arrhythmias.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The diisobutyryl ester of N-methyldopamine, ibopamine: evaluation of electrophysiological properties and arrhythmogenicity studies.
pubmed:publicationType
Journal Article