Linked Life Data

3706831

Source:http://linkedlifedata.com/resource/pubmed/id/3706831

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-6-18
pubmed:abstractText
An HPLC method for determination of dibekacin and amikacin in various biological samples is described. A step gradient elution and fluorescence detection carried out through an on line post column derivatization system with OPT is used. The chromatographic conditions allow simple and rapid preparation, so that a result can be obtained within twenty minutes. The small volume required (150 microliters) and the rapid sample clean-up are advantageous for routine use even in pediatric patients. The good sensitivity (dibekacin: 0,44 mumol/l - amikacin: 0,35 mumol/l), reproducibility and specificity indicate it to be suitable for pharmacokinetic studies. Results obtained from HPLC were in excellent agreement with those of FPIA for both dibekacin and amikacin (r greater than or equal to 0,98).
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-3898
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
[Rapid microdetermination of 2 aminoglycosides by high-performance liquid chromatography in the plasma, bile and urine. Correlation of high-performance liquid chromatography and fluorescence polarization for plasma assays].
pubmed:publicationType
Journal Article, English Abstract