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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1986-6-18
|
| pubmed:abstractText |
We have studied the capacity of a number of phosphate compounds to act in the double role as a phosphate source and a detoxifier of ferric chloride hydroxo compounds, i.e. as Fe(III) chelators. The tested compounds were: orthophosphate, trimetaphosphate, alpha-glycerophosphate, beta-glycerophosphate, phytic acid, and phosphorylcholine; the test organism the ciliate protozoon Tetrahymena thermophila, an animal cell; and the nutrient medium was synthetic, consisting solely of low-molecular-weight compounds. We assessed growth rates of cells in two experimental series. First, phosphate-starved cells were exposed to the tested phosphate compound as the only phosphate source and the ferric chloride concentrations were varied stepwise from 0 to 1000 microM. Second, we offered the cells orthophosphate as a phosphate source and selected phosphate compounds as chelators. The cell growth results allow the following conclusions: orthophosphate, trimetaphosphate, alpha-glycerophosphate, and beta-glycerophosphate are excellent phosphate sources; trimetaphosphate, alpha-glycerophosphate, beta-glycerophosphate, and phytic acid are excellent Fe(III) chelators; of the tested compounds trimetaphosphate, alpha-glycerophosphate, and beta-glycerophosphate are excellent in the double role as a phosphate source and a ferric chloride hydroxo detoxifier, i.e. as a Fe(III) chelator.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Ferric Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerophosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Iron Chelating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Phytic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Polyphosphates,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-glycerophosphoric acid,
http://linkedlifedata.com/resource/pubmed/chemical/beta-glycerophosphoric acid,
http://linkedlifedata.com/resource/pubmed/chemical/ferric chloride,
http://linkedlifedata.com/resource/pubmed/chemical/trimetaphosphoric acid
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0883-8364
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
177-9
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:3700321-Animals,
pubmed-meshheading:3700321-Cells, Cultured,
pubmed-meshheading:3700321-Chlorides,
pubmed-meshheading:3700321-Ferric Compounds,
pubmed-meshheading:3700321-Glycerophosphates,
pubmed-meshheading:3700321-Iron,
pubmed-meshheading:3700321-Iron Chelating Agents,
pubmed-meshheading:3700321-Phosphates,
pubmed-meshheading:3700321-Phosphorylcholine,
pubmed-meshheading:3700321-Phytic Acid,
pubmed-meshheading:3700321-Polyphosphates,
pubmed-meshheading:3700321-Tetrahymena
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Phosphate compounds as iron chelators in animal cell cultures.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|