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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1986-6-25
|
| pubmed:abstractText |
Reasons for delivering a non-uniform dose to the target volume are discussed. These include deliberate tailoring of dose to a non-uniform tumor burden or to a non-uniform expectation of the presence of disease, and undesired but unavoidable non-uniformities due to: technical factors; set-up uncertainty; and the need to avoid sensitive organs abutting the target volume. The consequences of non-uniform dose distributions are reviewed and it is suggested that: tumor control may be better characterized by the mean rather than the minimum target absorbed dose when the dose non-uniformity is not too great; modest dose deficits to small sub-volumes of the target volume may not be too deleterious; and modest dose increments to substantial sub-volumes of the target volume may be advantageous. Further modeling, and animal experiments in which tumors are non-uniformly irradiated are required to validate these hypotheses.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0360-3016
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
701-4
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1986
|
| pubmed:articleTitle |
Causes and consequences of inhomogeneous dose distributions in radiation therapy.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|