|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026046,
umls-concept:C0040549,
umls-concept:C0205177,
umls-concept:C0441472,
umls-concept:C0441712,
umls-concept:C0449432,
umls-concept:C1179435,
umls-concept:C1512571,
umls-concept:C1522492,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1986-6-3
|
|
pubmed:abstractText |
We show in vitro inhibitory effect of a mixture of uremic toxins on tubulin 6S polymerization. It proves the existence of a direct interaction protein-toxin where micro-tubule associated proteins are not involved. A similar phenomenom could occur in uremic neuropathy. The action mechanism of this interaction is quite different from that of classical tubulin inhibitors: Vinca alcaloïdes and colchicine. Finally we hypothesize about the active molecule.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0301-0430
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
25
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
212-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:3698354-Animals,
pubmed-meshheading:3698354-Chromatography, High Pressure Liquid,
pubmed-meshheading:3698354-Colchicine,
pubmed-meshheading:3698354-Humans,
pubmed-meshheading:3698354-Microscopy, Electron,
pubmed-meshheading:3698354-Microtubule-Associated Proteins,
pubmed-meshheading:3698354-Microtubules,
pubmed-meshheading:3698354-Swine,
pubmed-meshheading:3698354-Toxins, Biological,
pubmed-meshheading:3698354-Tubulin Modulators,
pubmed-meshheading:3698354-Uremia,
pubmed-meshheading:3698354-Vinca Alkaloids
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
Inhibition of microtubule formation by uremic toxins: action mechanism and hypothesis about the active component.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
|
