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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1988-2-23
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pubmed:abstractText |
The precursor rRNA of Tetrahymena thermophila contains a group I intervening sequence (IVS) that catalyzes its own excision to yield mature rRNA. The excised IVS catalyzes a number of cleavage/ligation reactions that are analogous to the transesterification reactions of splicing. We examined the behavior of a variety of 3'-truncated forms of the IVS and found several abbreviated molecules that retained catalytic activity. The reactivity of these molecules indicates that the site at which cleavage/ligation occurs lies in close proximity to all of the conserved sequence elements within the catalytic core of the IVS.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-11894905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-2412290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-2421916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-2430332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-2431151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-2431791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-2443161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-2579378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-3014350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-3021333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-3537808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-3647266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-3849344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-3865712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-3917861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-3941911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-4080546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-4084515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-409999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-6086458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-6186917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-6197186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-6200938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-6285310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-6297745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-6371808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-6757759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-6817818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-7040372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3697083-7099968
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9825-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3697083-Animals,
pubmed-meshheading:3697083-Base Sequence,
pubmed-meshheading:3697083-Catalysis,
pubmed-meshheading:3697083-Cloning, Molecular,
pubmed-meshheading:3697083-Cyclization,
pubmed-meshheading:3697083-Nucleic Acid Conformation,
pubmed-meshheading:3697083-RNA, Ribosomal,
pubmed-meshheading:3697083-RNA Precursors,
pubmed-meshheading:3697083-Tetrahymena
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pubmed:year |
1987
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pubmed:articleTitle |
Structure of the catalytic core of the Tetrahymena ribozyme as indicated by reactive abbreviated forms of the molecule.
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pubmed:affiliation |
Salk Institute for Biological Studies, San Diego, CA 92138.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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