Linked Life Data

3696468

Source:http://linkedlifedata.com/resource/pubmed/id/3696468

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1988-2-8
pubmed:abstractText
The putative gliotoxic compound, alpha-aminoadipic acid (AAA), has previously been reported to be a glial-selective toxin exerting its effects both in vivo and in vitro. This study sought to examine the effects of this compound on adult rat hippocampal astrocytes in vivo. Fourteen adult male Sprague-Dawley rats were injected with high concentrations of either the L-isomer or the racemic mixture of AAA into the dorsal hippocampal formation or corpus striatum. The animals were allowed to survive for times ranging from 4 to 48 h and the possible toxicity of the acid on astrocytes was monitored by glial fibrillary acidic protein (GFAP) immunocytochemistry. In every case, the GFAP-positive cells at the level of the injection site appeared identical, both in morphology and cell density, to control preparations. Based on our results, we conclude that AAA is not toxic to adult rat hippocampal astrocytes in vivo, nor could we confirm previous reports of toxicity to striatal astrocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Putative gliotoxin, alpha-aminoadipic acid, fails to kill hippocampal astrocytes in vivo.
pubmed:affiliation
Department of Anatomy, University of Utah School of Medicine, Salt Lake City 84132.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, Non-P.H.S.