Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1988-2-20
|
| pubmed:abstractText |
Hydropathic profiles can be considered as an approach to the three-dimensional structure of a protein and so their use for comparison of homologous proteins is proposed, as they provide information on relative structural conservativeness. A simple approach was developed for comparison of hydropathic profiles and applied to 19 lysozymes c of known primary structure. Trees were constructed in order to discover which method yielded the best estimation of the phenotypic differences between the proteins considered, by means of the goodness-of-fit criterion. Iterative methods, such as the Fitch-and-Margoliash and the unweighted-pair-group methods, gave a better fit than did a non-iterative method. When the hydropathic approach is used for comparison of lysozymes c, the enzyme obtained from chachalaca egg-white is placed closer to those from pheasant-like birds than to those of ducks; this result agrees with the morphological resemblance of the chachalaca to pheasant-like birds. Pigeon egg-white and equine milk lysozymes differ greatly in sequence from other lysozymes c and their hydropathic analysis shows important differences with respect to the other homologous enzymes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-5193
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
21
|
| pubmed:volume |
127
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
221-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1987
|
| pubmed:articleTitle |
A structural comparison of type c lysozymes based on their hydropathic profiles.
|
| pubmed:affiliation |
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad Complutense, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|