Linked Life Data

3693870

Source:http://linkedlifedata.com/resource/pubmed/id/3693870

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-2-20
pubmed:abstractText
The treatment of depressed patients with a fixed dose of amitriptyline is compared to treatment with an individualized dose calculated by means of a simple pharmacokinetic test. Clinical response and the development of side-effects are compared between the two groups of patients. Although the numbers in the groups were small, the clinical results lend little support to the concept of a therapeutic range of plasma drug concentrations for amitriptyline, and none of the plasma concentrations was high enough to produce serious toxic effects. No obvious clinical advantage was observed in the predicted dose treatment group as assessed by a reduction in depression ratings. The dose prediction test did however more than halve the variance in blood drug concentrations, and its usefulness in preventing high and potentially toxic concentrations is indisputable.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0268-1315
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
307-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Application of an individually predicted dosage of amitriptyline to the treatment of depression.
pubmed:affiliation
St. Bartholomew's Medical College, West Smithfield, London, U.K.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't