Linked Life Data

3691553

Source:http://linkedlifedata.com/resource/pubmed/id/3691553

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-2-2
pubmed:abstractText
Rho-1C5, a monoclonal antibody sensitive to phosphorylation of rhodopsin, bound to the retinal photoreceptor cell body region of dark-adapted but not light-adapted 8 to 13-day-old-rats. There was no cell body labeling visible either before or after this time, although the photoreceptor outer segments were labeled at all times from postnatal day 5 (PN5) onwards, in both light and dark adapted retinas. However, opsin was detectable in the photoreceptor cell body region from birth onwards using another rhodopsin antibody binding to a site unaffected by phosphorylation. Competitive inhibition radioimmunoassays also indicated light-dependent differences in Rho-1C5 binding at PN8 and adult. Biochemical studies showed light-dependent phosphorylation of rhodopsin at PN8, PN13 (just after eye opening) and adult. These data indicate that rhodopsin can be phosphorylated in a light-regulated manner early in development before eye opening and imply that photoactive chromophores can attach to opsin in the cell body as well as the outer segment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0171-9335
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
A phosphorylation-sensitive anti-rhodopsin monoclonal antibody reveals light-induced phosphorylation of rhodopsin in the photoreceptor cell body.
pubmed:affiliation
Laboratory of Neurobiology, Rockefeller University, New York, NY.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.