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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1988-2-9
|
| pubmed:abstractText |
Using a rat dermatosis model, produced by dietary essential fatty acid deficiency (EFAD), which is characterized by histological changes and elevated transepidermal water loss, changes in skin permeability were studied using [14C]-hydrocortisone (HC). Skin, serum and urinary levels of HC were measured, and absorption and excretion of HC in EFAD rats compared with that in control rats on a normal diet. This animal model has demonstrated the importance of the functional integrity of the horny layer in skin penetration.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0007-0963
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
117
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
607-15
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3689679-Administration, Topical,
pubmed-meshheading:3689679-Animals,
pubmed-meshheading:3689679-Anti-Inflammatory Agents,
pubmed-meshheading:3689679-Dietary Fats,
pubmed-meshheading:3689679-Disease Models, Animal,
pubmed-meshheading:3689679-Fatty Acids, Essential,
pubmed-meshheading:3689679-Female,
pubmed-meshheading:3689679-Hydrocortisone,
pubmed-meshheading:3689679-Permeability,
pubmed-meshheading:3689679-Rats,
pubmed-meshheading:3689679-Skin Absorption,
pubmed-meshheading:3689679-Skin Diseases
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Influence of an essential fatty acid deficient diet on absorption of topical hydrocortisone in the rat.
|
| pubmed:affiliation |
Centre International de Recherches Dermatologiques, Sophia Antipolis, Valbonne, France.
|
| pubmed:publicationType |
Journal Article
|