Linked Life Data

3689431

Source:http://linkedlifedata.com/resource/pubmed/id/3689431

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
1987-12-30
pubmed:abstractText
The metabolism of acetaldehyde was studied in isolated dog, rat and guinea-pig kidney-cortex tubules. In contrast with previous observations of Cederbaum and Rubin in rat kidney mitochondria (Archs Biochem. Biophys. 179, 46-66 1977) acetaldehyde was found to be metabolized by the tubules at high rates and in a dose-dependent manner at concentrations up to 5-10 mM. At high acetaldehyde concentrations (1-10 mM) acetaldehyde removal was accompanied by a high rate of acetate accumulation which explained most of the acetaldehyde metabolized in dog and guinea-pig but not in rat kidney tubules. These species differences in acetaldehyde metabolism can be explained by the differences in activities of aldehyde dehydrogenase (EC 1.2.1.3) and acetyl-CoA synthetase (EC6.2.1.1), the enzymes involved in renal acetaldehyde metabolism which were measured in the renal cortex of the three species. The acetaldehyde carbon removed and not accounted for by acetate accumulation was completely oxidized to CO2 as demonstrated by the measurement of [U-14C]-acetaldehyde conversion into 14CO2. At "physiological" acetaldehyde concentrations (0.1 and 0.2 mM) acetaldehyde utilization was also concentration-dependent but no acetate accumulation was observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3987-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Characteristics of acetaldehyde metabolism in isolated dog, rat and guinea-pig kidney tubules.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Alexis Carrel, Lyon, France.
pubmed:publicationType
Journal Article, In Vitro