Linked Life Data

3689429

Source:http://linkedlifedata.com/resource/pubmed/id/3689429

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
1987-12-30
pubmed:abstractText
(1) The effects of 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate (etomoxir), a candidate antiketonaemic and antidiabetic drug, on glucose turnover and recycling of glucose carbon in rats were determined using [3-3H, U-14C]glucose. (2) Etomoxir (Na salt) was infused continuously at a rate of 2 mg/hr in fasted male Wistar ab Boots rats (250-280 g) that had been maintained on a standard diet, or on a diet containing 0.1% of etomoxir for 10 days. (3) In rats treated acutely with etomoxir, plasma glucose concentrations were decreased by about 1 mM, glucose turnover was decreased by 14%, and recycling of glucose carbon by 30% compared with the controls infused with 0.14 M NaCl. (4) Infusion of etomoxir in rats chronically pretreated with etomoxir had little effect on plasma glucose concentrations, but increased glucose turnover and recycling of glucose carbon by 40%. (5) Acute infusion of etomoxir caused dramatic lowering of blood 3-hydroxybutyrate concentrations from 1 mM to about 0.03 mM with little change in other intermediary metabolites. (6) In rats chronically fed etomoxir, the proportion of pyruvate dehydrogenase in quadriceps muscle in the active form was 31% compared with 15% in the controls. (7) It was concluded that etomoxir in the acute dose given had only moderate effects on glucose turnover and that chronic administration of etomoxir caused increased glucose turnover and glucose recycling in the rat.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3917-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Glucose kinetics during acute and chronic treatment of rats with 2[6(4-chloro-phenoxy)hexyl]oxirane-2-carboxylate, etomoxir.
pubmed:affiliation
Department of Medicine, Medical School, University of Newcastle upon Tyne, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't