Linked Life Data

3688410

Source:http://linkedlifedata.com/resource/pubmed/id/3688410

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1988-1-20
pubmed:abstractText
The use of evoked potential recording is commonly employed for monitoring peripheral and central sensory functions during neurosurgical procedures. However, the neuronal structures studied must not be changed by the anesthetic agents used. In this connection, the influence of two anesthetics, fentanyl and enflurane, on evoked potentials was investigated under basic anesthesia. A total of 60 patients undergoing lumbar disc removal were included in the study. Somatosensory (SEP), auditory (AEP), and visual (VEP) evoked potentials were each recorded in 20 patients the day before operation. Basic anesthesia was induced with flunitrazepam, nitrous oxide, and pancuronium bromide. Following induction, recordings of evoked potentials were again made. One half of each group of 20 patients received increasing doses of fentanyl (1.8, 3.6, and 7.2 micrograms/kg in the somatosensory and auditory groups; 4.0 and 8.0 micrograms/kg in the visual group). The other half was given increasing inspiratory concentrations of enflurane (0.5, 1.0, and 1.5 vol.%). At each level of anesthesia, SEPs, AEPs or VEPs were recorded. As compared with preoperative recordings, post-stimulus latencies were virtually unaffected by the basic anesthesia. Fentanyl caused little increase in the latencies of middle-latency-SEPs and of peak P2 of the VEPs. With enflurane, however, the latencies of the SEPs were dose-dependently prolonged, in particular those of the later components (P25 to N55). The same was true for the peak P2 in the VEPs. AEPs were not changed at all. From the results it can be concluded that enflurane, but not fentanyl, impairs impulse conduction in central synaptic pathways.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0003-2417
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
548-54
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Effect of fentanyl and enflurane on sensory evoked potentials in the human in basic flunitrazepam/N2O anesthesia].
pubmed:affiliation
Institut für Anaesthesiologie, Universität Zürich.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract