Linked Life Data

3687922

Source:http://linkedlifedata.com/resource/pubmed/id/3687922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-1-7
pubmed:abstractText
Permutation models are introduced as a formal method for assigning significance to association matrices that assess the correlation of spouse, parent-offspring, and sibling similarity over an entire class of data transformations (usually, the class of all increasing functions). Analysis of 218 nuclear families who participated in the Stanford Five City Project revealed that parent and offspring triglyceride concentrations correlated more strongly when data transformations emphasized contrasts among low to moderate levels, and that high density lipoprotein (HDL) cholesterol correlated more strongly between family members with relatively higher HDL cholesterol concentrations. Application of family weights to the association matrices revealed a tendency for greater correlation among sibling triglyceride concentrations in larger families. Parent-child, mother-child, father-child, parent-daughter, and sibling total cholesterol concentrations correlated significantly for all monotonically increasing transformations (designated strong association), and father-daughter and parent-son cholesterol concentrations correlated significantly for most increasing transformations of the data (moderate association). There were fewer significant associations for plasma triglyceride concentrations: parent-child and sibling (both strong), parent-daughter and mother-daughter (both moderate), and mother-child (weak). HDL cholesterol showed no strong or moderate familial associations and was weakly associated only among siblings. Thus, concordance in familial lipoprotein levels appears to be restricted to a narrower range of values for triglycerides and HDL cholesterol than total cholesterol levels, possibly reflecting in part the influences of diet or other environmental factors on specific regions of the HDL cholesterol or triglyceride distributions in casual blood samples.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9262
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1126-40
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Permutation analyses of familial association arrays for lipoprotein concentrations in families of the Stanford Five City Project.
pubmed:affiliation
Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, CA 94305.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.