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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1988-1-15
|
| pubmed:abstractText |
The renal glomerular and tubular effects of the platelet-activating factor (Paf-acether) were studied, by clearance techniques, in acutely thyroparathyroidectomized Brattleboro rats infused with Paf-acether at the rate of 1.25, 2.5 or 5 ng/min/100 g bw. Paf-acether infusion was accompanied by decreases of urinary flow rate, calcium, and magnesium urinary excretion, whereas decreases of mean arterial pressure and glomerular filtration rate did not exceed 20% of control values for the highest perfusion rate of Paf-acether. These changes in tubular function were partially (calcium excretion) or totally (urinary flow rate and magnesium excretion) reversed after Paf-acether infusion was discontinued. Sodium and potassium excretion did not vary significantly during Paf-acether infusion, but increased dramatically after discontinuation of Paf-acether infusion. Infusion of lyso-Paf-acether or ethoxy-Paf-acether, two biologically less active structural analogues of Paf-acether, did not elicit any change in the variables studied. These data suggest that Paf-acether, when locally released by the kidney in pathological conditions, might affect both glomerular and tubular functions, possibly through different mechanisms.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0065-4299
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
165-70
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1987
|
| pubmed:articleTitle |
Renal effects of platelet-activating factor in the rat.
|
| pubmed:affiliation |
INSERM U.251, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|