Linked Life Data

3685151

Source:http://linkedlifedata.com/resource/pubmed/id/3685151

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-1-12
pubmed:abstractText
The effects of intraperitoneally injected pancreatic glucagon on feeding and on plasma levels of pancreatic glucagon as well as on blood glucose levels and liver glycogen content were investigated in rats, in order to test the physiological relevance of exogenous glucagon's satiety effect. The rats were intraperitoneally injected with various doses of glucagon [60, 240 or 480 micrograms/kg body weight (b.wt.)] or vehicle when they started to eat after a 12 hr period of food deprivation. Only the highest dose of pancreatic glucagon (480 micrograms/kg b.wt.) decreased the size and duration of the first meal after injection. Hepatic vein, hepatic portal vein and aortal plasma pancreatic glucagon levels were increased about 10 fold by 60 and 240 micrograms/kg b.wt. of glucagon and about 30 to 70 fold by 480 micrograms/kg b.wt. of glucagon. All glucagon doses reduced liver glycogen content and increased hepatic vein blood glucose levels similarly. The results indicate that decreased feeding after intraperitoneal injection of glucagon is a pharmacological effect of the hormone, at least under the conditions tested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Decreased feeding and supraphysiological plasma levels of glucagon after glucagon injection in rats.
pubmed:affiliation
Institut für Veterinär-Physiologie der Universität Zürich, Switzerland.
pubmed:publicationType
Journal Article