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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1987-12-21
|
| pubmed:abstractText |
A quantitative method is described for the measurement of N-mononitrosopiperazine (NPIP) and N,N'-dinitrosopiperazine (DNPIP) in drug formulations containing piperazine, using a gas chromatograph interfaced to a thermal energy analyzer (GC/TEA). The method has detection limits of 20 ppb for NPIP and 12 ppb for DNPIP. In a survey of 6 products available on the Canadian market, all contained NPIP at levels of 0.38-15.3 micrograms NPIP/g piperazine and none contained any detectable amount of DNPIP.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0004-5756
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
840-1
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3680121-Chromatography, Gas,
pubmed-meshheading:3680121-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:3680121-Indicators and Reagents,
pubmed-meshheading:3680121-Nitrosamines,
pubmed-meshheading:3680121-Piperazines,
pubmed-meshheading:3680121-Tetraethylammonium Compounds
|
| pubmed:articleTitle |
Analysis of piperazine drug formulations for N-nitrosamines.
|
| pubmed:affiliation |
Health and Welfare Canada, Bureau of Drug Research, Ottawa, Ontario.
|
| pubmed:publicationType |
Journal Article
|