Linked Life Data

3679353

Source:http://linkedlifedata.com/resource/pubmed/id/3679353

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
84
pubmed:dateCreated
1988-1-12
pubmed:abstractText
Freshly excised rat oesophagus and other tissues metabolize N-nitrosomethyl-n-amylamine (NMAA) to 2-, 3-, 4- and 5-hydroxy-NMAA (HO-NMAA), and 3- and 4-oxo-NMAA. We examined the development of this metabolism in MRC-Wistar rats and Syrian hamsters. In rats, oesophagus showed maximum metabolism at nine days of age, and forestomach showed considerable metabolism at three days, but none in adults. In newborn hamsters, oesophagus showed 10.4%; and in three-day hamsters, forestomach showed 4.9% metabolism, despite low or no metabolism by the adult tissues. Clearance of NMAA (25 mg/kg) from rat blood had a half-life of 21 min. The blood also contained considerable amounts of 4-oxo- and 4-HO-NMAA. Incubation of adult oesophagus and liver slices with 3H-labelled NMAA produced DNA labelling, including labelled N7-and O6-methylguanine, with 14 times higher specific radioactivity in DNA from oesophagus than from liver. O6-Methylguanine was also measured by radioimmunoassay.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5038
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
144-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Metabolism of the oesophageal carcinogen N-nitrosomethylamylamine: changes with age, clearance from blood and DNA alkylation.
pubmed:affiliation
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68105.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't