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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1987-12-30
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pubmed:abstractText |
The brain topographical distribution of type II 5'-monodeiodinase (5'D-II), which converts thyroxine (T4) to triiodothyronine (T3), was studied in euthyroid and hypothyroid rats. Low levels of 5'D-II activity were detected in the median eminence, but not in any other brain regions of euthyroid rats. The arcuate nucleus and median eminence were also the sites of highest 5'D-II activity in brains of hypothyroid rats. Under these conditions, the paraventricular nucleus contained almost no detectable 5'D-II, while intermediate enzyme activity was present in other medial basal hypothalamic sites.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
420
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
194-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3676753-Animals,
pubmed-meshheading:3676753-Arcuate Nucleus,
pubmed-meshheading:3676753-Brain,
pubmed-meshheading:3676753-Hypothalamus,
pubmed-meshheading:3676753-Hypothyroidism,
pubmed-meshheading:3676753-Iodide Peroxidase,
pubmed-meshheading:3676753-Male,
pubmed-meshheading:3676753-Median Eminence,
pubmed-meshheading:3676753-Methimazole,
pubmed-meshheading:3676753-Rats,
pubmed-meshheading:3676753-Rats, Inbred Strains,
pubmed-meshheading:3676753-Thyroid Gland,
pubmed-meshheading:3676753-Thyroxine,
pubmed-meshheading:3676753-Triiodothyronine
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pubmed:year |
1987
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pubmed:articleTitle |
The regional hypothalamic distribution of type II 5'-monodeiodinase in euthyroid and hypothyroid rats.
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pubmed:affiliation |
Department of Neurology, Massachusetts General Hospital, Boston 02114.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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