Linked Life Data

3676730

Source:http://linkedlifedata.com/resource/pubmed/id/3676730

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1988-1-11
pubmed:abstractText
The quantitative 2-[14C]deoxyglucose autoradiographic method was used to study the effects of the acute administration of a sedative anticonvulsant dose of diazepam (2 mg/kg) on rat brain energy metabolism. This benzodiazepine was injected to rats chronically treated for two weeks either by caffeine (10 mg/kg/day) or by saline. After the administration of diazepam to saline-treated rats, average glucose utilization of the brain as a whole was reduced by 21% and rates of glucose utilization were deeply decreased in frontal and auditory cortex, mammillary body, lateral thalamus, medial and lateral geniculate. In caffeine-treated rats, the administration of diazepam induced the same effects of brain energy metabolism as in saline-treated rats. The results of the present study indicate that diazepam mainly decreases glucose utilization in structures widely believed to mediate anxiety.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
419
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
272-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Caffeine-diazepam interaction and local cerebral glucose utilization in the conscious rat.
pubmed:affiliation
INSERM U.272, Pathologie et Biologie du Développement Humain, Université de Nancy I, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't