Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1988-1-15
pubmed:abstractText
We performed argon laser trabeculoplasty in one eye in each of three cynomolgus monkeys, leaving the contralateral eyes as controls. Four weeks later in both eyes of each monkey we infused cationized ferritin as a tracer of the aqueous outflow pathways for 30-40 minutes before fixation. In the control eyes cationized ferritin was found throughout the conventional aqueous outflow tract, labelling trabecular endothelial cells, both inner and outer walls of Schlemm's canal, and the collecting channels. No permeation of cationized ferritin through continuous cellular layers such as the corneal endothelium was detected. In the lasered spots of the treated eyes cationized ferritin was found to label the cellular sheet covering the trabecular scar at the lasered site, but no tracer was detected within the scar or in Schlemm's canal immediately beneath. In contrast in adjacent non-lasered regions the trabecular cells, the observed juxta-canalicular herniations, and the vacuoles of the inner wall as well as Schlemm's canal itself were extensively labelled. Our findings suggest impermeability to aqueous humour flow through the actual lasered lesion, with shift of flow to adjacent, non-lasered regions. In the normal monkey these regions compensate structurally and functionally in ways that may help to deal with this diverted flow.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-13605338, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-3997413, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-403150, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-4051857, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-4339120, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-4623937, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-4695446, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-49331, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-5528726, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-575877, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-6174475, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-6207040, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-6462622, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-6493712, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-6504504, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-6524729, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-6541904, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-6885314, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-7088502, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-71846, http://linkedlifedata.com/resource/pubmed/commentcorrection/3676149-7298275
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-1161
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
776-81
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Alterations of aqueous humour outflow following argon laser trabeculoplasty in monkeys.
pubmed:affiliation
Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't