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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1987-12-16
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pubmed:abstractText |
Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been reported to cause lactic acidosis and other adverse effects. We describe a rapid gas chromatographic assay method for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions. The pharmacokinetics were nonlinear, based on a saturable clearance. The apparent first-order half-life was 2.3 +/- 0.7 h. There was no evidence of lactic acidosis, hemolysis, or increase in osmolality at 3-15 g/m2 PG infused over periods of 4 h.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0163-4356
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
255-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3672566-Adult,
pubmed-meshheading:3672566-Female,
pubmed-meshheading:3672566-Humans,
pubmed-meshheading:3672566-Infusions, Intravenous,
pubmed-meshheading:3672566-Male,
pubmed-meshheading:3672566-Middle Aged,
pubmed-meshheading:3672566-Propylene Glycol,
pubmed-meshheading:3672566-Propylene Glycols
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pubmed:year |
1987
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pubmed:articleTitle |
Propylene glycol pharmacokinetics and effects after intravenous infusion in humans.
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pubmed:affiliation |
Department of Haematology, St. Radboud University Hospital, Nijmegen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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