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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1987-12-14
|
| pubmed:abstractText |
Topically administered salbutamol was extremely effective in suppressing immediate allergic conjunctivitis in the guinea pig; a dose as low as 0.1% elicited 98% inhibition. Topical pretreatment with 1% propranolol completely blocked the suppressant action of 0.1% salbutamol. This was also the case after systemic propranolol (1 mg/kg SC); the beta-adrenoceptor antagonist itself has no effect on antigen-induced inflammation. The effect of 0.1% salbutamol was unaltered by pretreatment with the specific beta 1-adrenoceptor antagonist betaxolol (1 mg/kg SC). In marked contrast, the suppressant action of 0.1% salbutamol was profoundly inhibited by pretreatment with the selective beta 2-adrenoceptor antagonist ICI-118,551 (0.5 mg/kg SC). The experiments employing beta-adrenoceptor antagonists unequivocally demonstrate that the salbutamol suppression of immediate allergic conjunctivitis in the guinea pig is mediated via the activation of beta 2-adrenoceptors. The methylxanthine phosphodiesterase inhibitor theophylline was active after oral administration, 50 mg/kg eliciting an 80% inhibition. Theophylline was inactive topically at 1% and 5%, but this could be due to the fact that the compound was insoluble at these concentrations. Thus, procedures that elevate cyclic-AMP levels suppress immediate hypersensitivity reactions in the guinea pig conjunctiva. Whether or nor this offers an alternative approach to treat allergic conjunctivitis in humans remains to be determined.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0721-832X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
225
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
331-4
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3666475-Administration, Oral,
pubmed-meshheading:3666475-Administration, Topical,
pubmed-meshheading:3666475-Albuterol,
pubmed-meshheading:3666475-Animals,
pubmed-meshheading:3666475-Conjunctivitis, Allergic,
pubmed-meshheading:3666475-Dose-Response Relationship, Drug,
pubmed-meshheading:3666475-Female,
pubmed-meshheading:3666475-Guinea Pigs,
pubmed-meshheading:3666475-Propranolol,
pubmed-meshheading:3666475-Theophylline
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
The ability of salbutamol and theophylline to suppress immediate allergic conjunctivitis in the guinea pig.
|
| pubmed:affiliation |
Centre de Recherche, Merck Sharp & Dohme-Chibret, Riom, France.
|
| pubmed:publicationType |
Journal Article
|