Linked Life Data

3666051

Source:http://linkedlifedata.com/resource/pubmed/id/3666051

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-11-27
pubmed:abstractText
Insulin antibodies, insulin complexes, T-cell subsets and T-cells bearing surface antigens indicating early activation were studied in 35 and 24 infants of diabetic and of normal mothers respectively, which were compared with normal adult control subjects. Anti-insulin antibodies were evaluated using a modified version of Andersen's method, insulin complexes were assessed by a method developed by us; total T cells, helper/inducer and cytotoxic/suppressor T lymphocytes, and early activated T lymphocytes were determined using the monoclonal antibodies OKT3, OKT4, OKT8 and 4F2 respectively. The presence of insulin antibodies was correlated to macrosomia, hypoglycaemia and respiratory distress syndrome. Insulin-anti-insulin complexes were found in some of the neonates and were likely to have been formed by maternal antibodies and insulin from the neonate. Modifications of T-cell subsets were found in the neonates both of diabetic and of normal mothers. --Despite the presence of these immune abnormalities in some infants of diabetic mothers, the clinical onset of diabetes was not diagnosed in any of the cases studied. Nevertheless, the immunological abnormalities in neonates of diabetic mothers have short-term pathogenetic effects which raises the question of their possible long-term effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0232-7384
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
333-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Humoral and cellular immune abnormalities in neonates of diabetic mothers: any pathological role?
pubmed:affiliation
Department of Endocrinology 1, University of Rome, Italy.
pubmed:publicationType
Journal Article