Linked Life Data

3666027

Source:http://linkedlifedata.com/resource/pubmed/id/3666027

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-12-14
pubmed:abstractText
The role of intracellular sodium activity (aiNa) in the inotropy of a low concentration of strophanthidin (5 X 10(-8 M) was studied in sheep cardiac Purkinje fibers by recording contractile force, aiNa and transmembrane potentials under conditions that vary aiNa. High [Na]O, strophanthidin and tetrodotoxin (TTX) changed force and aiNa in a closely related manner: on logarithmic coordinates, the data were well fitted by a single line obtained through the regression equation F = b (aiNa)s where b represents the intercept and s the slope of the relation. With low strophanthidin, force increases as a linear function of (aiNa) approximately 5 and with high [Na]O as a linear function of (aiNa) approximately 6. However, the combined administration of high [Na]O and strophanthidin results in a potentiated inotropic effect as force becomes a linear function of (aiNa) approximately 14. This potentiation and its abolition by TTX suggests that factors other than aiNa powerfully modify the inotropy of a low strophanthidin concentration.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-65
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Strophanthidin and force regulation by intracellular sodium activity in cardiac Purkinje fibers.
pubmed:affiliation
Department of Physiology, State University of New York, Brooklyn 11203.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.