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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
22
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pubmed:dateCreated |
1987-12-17
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pubmed:abstractText |
Amplification of c-erbB-2 was at least three times more frequent in breast cancer than in most other types of carcinoma, and was not found in sarcomas or hematological malignancies. Amplification of c-erbB-2 was found in 15 of 86 primary breast cancers and in 3 of 12 secondary breast cancers. Amplification was more common in breast tumors of advanced stage, and in tumors which had metastasized to regional lymph nodes sites. Gene amplification was observed in 21% (4 of 19) of primary tumors which recurred within 3 years of mastectomy and in 6% (2 of 32) of nonrecurrent tumors.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-5472
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
47
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
6123-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3664511-Breast Neoplasms,
pubmed-meshheading:3664511-Female,
pubmed-meshheading:3664511-Gene Amplification,
pubmed-meshheading:3664511-Gene Frequency,
pubmed-meshheading:3664511-Humans,
pubmed-meshheading:3664511-Lymphatic Metastasis,
pubmed-meshheading:3664511-Neoplasm Metastasis,
pubmed-meshheading:3664511-Neoplasms,
pubmed-meshheading:3664511-Prognosis,
pubmed-meshheading:3664511-Proto-Oncogenes
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pubmed:year |
1987
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pubmed:articleTitle |
Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.
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pubmed:affiliation |
Department of Medicine, University of California, Los Angeles 90024.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|